To date, there have been very few cases of children being seriously affected by SARS-Cov-2 respiratory illness. London and the West Midlands have been the epicenters in the UK. As of 28th May 2020, there have been an estimated 269,127 confirmed cases reported in the UK with over 37,837 deaths. The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease (COVID-19), has rapidly spread worldwide. We believe that our multi-disciplinary team approach was crucial for the good short-term outcomes.
ROYAL TS V2 SERIES
Our entire cohort with PIMS-TS had cardiac involvement and this degree of involvement is significantly more than other published series and emphasizes the need for specialist cardiac review. All patients were discharged alive and twelve (80%) have been reviewed since. Improvement in cardiac biochemical markers was closely followed by improvement in ECG/echocardiogram. Ten (67%) needed inotropes and/or vasopressors. ECG abnormalities were present in 9 (60%) which normalized in 6 by discharge. Fourteen (93%) had coronary artery abnormalities, with normalization in 6. Left Ventricular ejection fraction was reduced in 12 (80%), fractional shortening in 8 (53%) with resolution in all but 2. Transient valve regurgitation was present in 10 patients (67%). All showed raised inflammatory/cardiac markers (CRP, ferritin, Troponin I, CK and pro-BNP). Fifteen children with median age of 8.8 (IQR 6.4–11.2) years were included, all were from African/Afro-Caribbean, South Asian, Mixed or other minority ethnic groups. Data on ECG and echocardiogram were retrospectively analyzed along with demographics, clinical features and blood parameters. Single-center observational study of children with PIMS-TS from 10th April to 9th May 2020. We describe cardiac findings and short-term outcomes in children with PIMS-TS at a tertiary children’s hospital. However, the recently reported hyperinflammatory syndrome with overlapping features of Kawasaki disease and toxic shock syndrome-“Paediatric Inflammatory Multisystem Syndrome-temporally associated with SARS-CoV-2” (PIMS-TS) has caused concern. Children were relatively spared during COVID-19 pandemic.